Research
Dr. Fotuhi began his research as a graduate student in the department of neuroscience at Johns Hopkins University in 1987. He studied the cellular and biochemical properties of glutamate receptors in the brain that are implicated in stroke and neurodegenerative conditions. He continued his work as a post-doctoral fellow at Massachusetts General Hospital and studied the distribution of subtypes of glutamate receptors in the area of the brain that is critical for learning and memory, the hippocampus. His subsequent research as an assistant professor of neurology at Johns Hopkins and the director of Center for Memory and Brain Health at Sinai hospital focused on the role of NSAIDs and nutrition (especially anti-oxidant vitamins and omega-3 fatty acids) on brain performance in elderly. He then analyzed the neuroscience literature about the role of diabetes, obesity, concussion, and hypertension in causing hippocampal brain atrophy with aging and realized that a great deal of late life dementia can be attributed to modifiable risk factors associated with healthy vs un-healthy lifestyle choices.
Based on these findings, Dr. Fotuhi formed an independent brain center in 2011 and developed a multi-disciplinary “brain fitness program” for patients with cognitive impairment due to aging, vascular diseases, and/or post-concussive disorder. This program has been quite effective in improving the cognitive function in his patients and, in some cases, there is a measurable increases in the volume of the hippocampus. Dr. Fotuhi is now interested in optimizing this brain rehabilitation program for patients with other neurological conditions
Publications
A 12-Week “Brain Fitness Program” for Treating Patients with MCI
The Challenge and Public Health Implications of Alzheimer Overdiagnosis in the Oldest Old
Factors Associated with Resistance to Dementia Despite High Alzheimer Disease Pathology
Antioxidant intake and cognitive function of elderly men and women
Contrasting lmmunohistochemical Localizations Novel K+ Channels of the Shah Subfamily
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
Facilitation of Feeding by Nucleus Accumbens Amphetamine Injections: Latency and Speed Measures
